Methyllithium solution, 1.6 M in diethyl ether - 100ML

Description

1.6 M in diethyl ether

Synonym: Lithium methanide, MeLi

CAS Number 917-54-4

Empirical Formula (Hill Notation) CH3Li

Molecular Weight 21.98

General description

Methyllithium is an organolithium reagent mainly used for deprotonation and as a source of methyl anion. It is a strong base and a strong nucleophile.

Application

Methyllithium solution (1.6M in diethyl ether) has been used for the asymmetric allylic alkylation (AAA) of allylic electrophiles in the presence of a chiral copper catalyst. This protocol leads to the C-C bond formation of tertiary and quaternary stereogenic centers with high enantioselectivity. It can also be used for the synthesis of (−)-salsolidine by reacting with 6,7-dimethoxy-3,4-dihydroisoquinoline in the presence of (−)-sparteine as a chiral ligand.

Packaging

1 L in Sure/Seal™

The 25 mL Sure/Seal™ bottle is recommended as a single-use bottle. Repeated punctures will likely result in decreased performance of product.

View returnable container options.

4×25, 50, 100, 4×100, 800 mL in Sure/Seal™

8, 18 L in Kilo-Lab™

Safety Information

Symbol GHS02, GHS05, GHS07

Signal word Danger

Hazard statements H225-H250-H260-H302-H314-H336

Precautionary statements P210-P222-P223-P231 + P232-P370 + P378-P422

Supplemental Hazard Statements May form explosive peroxides., Repeated exposure may cause skin dryness or cracking.

RIDADR UN 3394 4.3(4.2) / PGI

WGK Germany 1

Flash Point(F) 1.4 °F

Flash Point(C) -17 °C