Lithium diisopropylamide solution - 100ML

Description

2.0 M in THF/heptane/ethylbenzene

Synonym: LDA

CAS Number 4111-54-0

Linear Formula [(CH3)2CH]2NLi

Molecular Weight 107.12

General description

Lithium diisopropylamide solution (LDA) is a sterically hindered non-nucleophilic strong base widely used in organic synthesis.

Application

Lithium diisopropylamide solution (LDA) can be used:

• As an initiator in the anionic polymerization of D,L-lactide and methyl methacrylate.

• To facilitate ester enolization.

• To convert carboxylic acids to enediolate intermediates for preparing trifluoromethyl ketones.

• In ortho-lithiation of arylsulfonyloxazolidinones to prepare N-substituted saccharin analogs.

• To catalyze ortholithiation and Fries rearrangement of aryl carbamates.

• As a promoter in the isomerization of allylic ethers to (Z)-propenyl ethers.

Packaging

4×25, 100, 4×100, 800 mL in Sure/Seal™

The 25 mL Sure/Seal™ bottle is recommended as a single-use bottle. Repeated punctures will likely result in decreased performance of product.

Safety Information

Symbol  GHS02, GHS05, GHS07, GHS08, GHS09

Signal word Danger

Hazard statements H225-H304-H314-H335-H336-H351-H373-H411

Precautionary statements P210-P260-P273-P280-P301 + P310-P301 + P330 + P331-P303 + P361 + P353-P304 + P340 + P310-P305 + P351 + P338 + P310-P370 + P378-P391

Supplemental Hazard Statements May form explosive peroxides., Reacts violently with water.

RIDADR UN3399 - class 4.3 - PG 2 - EHS - Organometallic substance, liquid, water-reactive, flammable, HI: all (not BR)

WGK Germany 3

Flash Point(F) 35.6 °F

Flash Point(C) 2 °C