Isopropylmagnesium chloride lithium chloride complex solution - 800ML

Description

1.3 M in THF

Synonym: Turbo Grignard

Linear Formula (CH3)2CHMgCl · LiCl

Molecular Weight 145.24

Application

Reagent for Selective Metalations

Used for:

• Preparation of functionalized acyclic alkenyl magnesium reagents/preparation of 1,2-diketones

• Preparation of cyclic alkenyl and dienyl magnesium reagents

• Preparation of functionalized triazenes/preparation of carbazoles

• Regioselective functionalization of trisubstituted pyridines

• Electrophilic amination for preparation of amines

• Preparation of Grignards reagents in the presence of masked ketones and aldehydes (using readily deprotectable silylated cyanohydrins)

• Preparation of Benzylic Grignards via Sulfur-Magnesium exchange

• Functionalization via I-Mg Exchange of unprotected aromatic and heteroaromatic carboxylic acids

• Functionalization via I-Mg Exchange of unprotected imidazoles

• Pyridyne formation

• Functionalization of cyclopentene derivatives

• Preparation of 2,3-functionalized furans, benzofurans, and thiophenes

• Stereoselective synthesis of substituted cyclopropanes

Reagent used with CH3MgCl/LiCl to affect magnesium-halogen exchange on unprotected aryl carboxylic acids.[1]

Packaging

2 L in Sure/Seal™

4×25, 100, 800 mL in Sure/Seal™

The 25 mL Sure/Seal™ bottle is recommended as a single-use bottle. Repeated punctures will likely result in decreased performance of product.

Safety Information

Symbol  GHS02, GHS05, GHS07, GHS08

Signal word Danger

Hazard statements H225-H314-H335-H351

Precautionary statements P210-P260-P280-P305 + P351 + P338-P370 + P378-P403 + P235

Supplemental Hazard Statements May form explosive peroxides., Reacts violently with water.Personal Protective Equipment Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter

RIDADR UN 3399BC 4.3(3) / PGII

WGK Germany 3

Flash Point(F) 1.4 °F

Flash Point(C) -17 °C